Amedco - Quiz
New Frontiers in Intestinal Failure-ENDURING MOC
1 - The following statements are true regarding native glucagon-like peptide 2 except:
A - It is produced by L-cells found in the ileum and cecum.
B - GLP-2 is a potent intestinotrophic hormone which increases crypt cell proliferation, and visceral blood flow and decreases gastro-intestinal motility and gastric secretions.
C - Neuroendocrine cells, myofibroblasts and enteric neurons have GLP-2 receptors.
D - GLP-2 is inactivated by dipeptidyl dipeptidase and has a relatively long half-life.
2 - The following statements are true regarding Teduglutide®:
A - It is identical to native GLP-2 except for a substitution of alanine by glycine at second position of N-terminus, resulting in an extended T½.
B - It was approved in 2012 by the United States FDA for adults with short-bowel syndrome who are dependent on parenteral nutrition, and may be associated with improved absorption and decreased parenteral nutrition needs.
C - It can be associated with side effects including but not limited to abdominal pain, nausea, and gastrointestinal stomal complications.
D - All of the above are true.
3 - How do you diagnose essential fatty acid status in a patient on SMOFlipid® or Omegaven®
A - Low mead acid
B - Elevated mead acid
C - Low linoleic acid
D - Low alpha linolenic acid
E - B, C and D
4 - According to the findings of Modi and colleagues in 2008, which has improved greatest over the past decade?
A - Reduction in the incidence of NEC
B - Mortality rate for all causes of short gut
C - Median duration of parenteral needs in short gut
D - Percentage of patients achieving enteral autonomy.
5 - The presence of donor specific antibodies:
A - Reduces graft salvage four fold if they persist after transplant
B - Is ominous if they appear prior to transplant
C - Has no effect upon outcomes
D - Is more likely to persist in patients undergoing combined liver bowel transplant than in patients undergoing isolated bowel transplant.
6 - The frequency of isolated bowel transplants has declined by a greater magnitude than have liver-bowel transplants.
A - True
B - False
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